Genetics

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Autophagy Is Required for Sortilin-Mediated Degradation of Apolipoprotein B100Novelty and Significance
Jaume Amengual, Liang Guo, Alanna Strong, Julio Madrigal-Matute, Haizhen Wang, Susmita Kaushik, Jeffrey L. Brodsky, Daniel J. Rader, Ana Maria Cuervo and Edward A. Fisher

Circulation Research. 2018;122:568-582, originally published January 4, 2018
https://doi.org/10.1161/CIRCRESAHA.117.311240

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Short Leukocyte Telomere Length Precedes Clinical Expression of AtherosclerosisNovelty and SignificanceThe Blood-and-Muscle Model
Athanase Benetos, Simon Toupance, Sylvie Gautier, Carlos Labat, Masayuki Kimura, Pascal M. Rossi, Nicla Settembre, Jacques Hubert, Luc Frimat, Baptiste Bertrand, Mourad Boufi, Xavier Flecher, Nicolas Sadoul, Pascal Eschwege, Michèle Kessler, Irene P. Tzanetakou, Ilias P. Doulamis, Panagiotis Konstantopoulos, Aspasia Tzani, Marilina Korou, Anastasios Gkogkos, Konstantinos Perreas, Evangelos Menenakos, Georgios Samanidis, Michail Vasiloglou-Gkanis, Jeremy D. Kark, Serguei Malikov, Simon Verhulst and Abraham Aviv

Circulation Research. 2018;122:616-623, originally published December 14, 2017
https://doi.org/10.1161/CIRCRESAHA.117.311751

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Deficiency of Natriuretic Peptide Receptor 2 Promotes Bicuspid Aortic Valves, Aortic Valve Disease, Left Ventricular Dysfunction, and Ascending Aortic Dilatations in MiceNovelty and Significance
Mark C. Blaser, Kuiru Wei, Rachel L.E. Adams, Yu-Qing Zhou, Laura-lee Caruso, Zahra Mirzaei, Alan Y.-L. Lam, Richard K.K. Tam, Hangjun Zhang, Scott P. Heximer, R. Mark Henkelman and Craig A. Simmons

Circulation Research. 2018;122:405-416, originally published December 22, 2017
https://doi.org/10.1161/CIRCRESAHA.117.311194

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Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery DiseaseNovelty and Significance
Pim van der Harst and Niek Verweij

Circulation Research. 2018;122:433-443, originally published December 6, 2017
https://doi.org/10.1161/CIRCRESAHA.117.312086

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MicroRNA-100 Suppresses Chronic Vascular Inflammation by Stimulation of Endothelial AutophagyNovelty and Significance
Franziska Pankratz, Catherine Hohnloser, Xavier Bemtgen, Caterina Jaenich, Sheena Kreuzaler, Imo Hoefer, Gerard Pasterkamp, Justin Mastroianni, Robert Zeiser, Christian Smolka, Laura Schneider, Julien Martin, Maike Juschkat, Thomas Helbing, Martin Moser, Christoph Bode and Sebastian Grundmann

Circulation Research. 2018;122:417-432, originally published December 5, 2017
https://doi.org/10.1161/CIRCRESAHA.117.311428

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Adenosine-to-Inosine Editing of MicroRNA-487b Alters Target Gene Selection After Ischemia and Promotes NeovascularizationNovelty and Significance
Reginald V.C.T. van der Kwast, Eva van Ingen, Laura Parma, Hendrika A.B. Peters, Paul H.A. Quax and A. Yaël Nossent

Circulation Research. 2018;122:444-456, originally published December 28, 2017
https://doi.org/10.1161/CIRCRESAHA.117.312345

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Somatic Mutations and Clonal HematopoiesisUnexpected Potential New Drivers of Age-Related Cardiovascular Disease
José J. Fuster and Kenneth Walsh

Circulation Research. 2018;122:523-532, originally published February 1, 2018
https://doi.org/10.1161/CIRCRESAHA.117.312115

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RNA EditingUnexplored Opportunities in the Cardiovascular System
Shizuka Uchida and Steven P. Jones

Circulation Research. 2018;122:399-401, originally published February 1, 2018
https://doi.org/10.1161/CIRCRESAHA.117.312512

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Distinct Cellular Mechanisms Underlie Smooth Muscle Turnover in Vascular Development and RepairNovelty and Significance
Urmas Roostalu, Bashar Aldeiri, Alessandra Albertini, Neil Humphreys, Maj Simonsen-Jackson, Jason K.F. Wong and Giulio Cossu

Circulation Research. 2018;122:267-281, originally published November 22, 2017
https://doi.org/10.1161/CIRCRESAHA.117.312111

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Anthracycline CardiotoxicityWorrisome Enough to Have You Quaking?
Daniel Bernstein

Circulation Research. 2018;122:188-190, originally published January 18, 2018
https://doi.org/10.1161/CIRCRESAHA.117.312395

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