Genetics

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Exploring the Causal Pathway From Telomere Length to Coronary Heart DiseaseNovelty and SignificanceA Network Mendelian Randomization Study
Yiqiang Zhan, Ida K. Karlsson, Robert Karlsson, Annika Tillander, Chandra A. Reynolds, Nancy L. Pedersen and Sara Hägg

Circulation Research. 2017;121:214-219, originally published May 17, 2017
https://doi.org/10.1161/CIRCRESAHA.116.310517

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Divergent Requirements for EZH1 in Heart Development Versus RegenerationNovelty and Significance
Shanshan Ai, Xianhong Yu, Yumei Li, Yong Peng, Chen Li, Yanzhu Yue, Ge Tao, Chuanyun Li, William T. Pu and Aibin He

Circulation Research. 2017;121:106-112, originally published May 16, 2017
https://doi.org/10.1161/CIRCRESAHA.117.311212

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Protein-Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart DiseaseNovelty and Significance
Akihiro Nomura, Hong-Hee Won, Amit V. Khera, Fumihiko Takeuchi, Kaoru Ito, Shane McCarthy, Connor A. Emdin, Derek Klarin, Pradeep Natarajan, Seyedeh M. Zekavat, Namrata Gupta, Gina M. Peloso, Ingrid B. Borecki, Tanya M. Teslovich, Rosanna Asselta, Stefano Duga, Piera A. Merlini, Adolfo Correa, Thorsten Kessler, James G. Wilson, Matthew J. Bown, Alistair S. Hall, Peter S. Braund, David J. Carey, Michael F. Murray, H. Lester Kirchner, Joseph B. Leader, Daniel R. Lavage, J. Neil Manus, Dustin N. Hartze, Nilesh J. Samani, Heribert Schunkert, Jaume Marrugat, Roberto Elosua, Ruth McPherson, Martin Farrall, Hugh Watkins, Jyh-Ming J. Juang, Chao A. Hsiung, Shih-Yi Lin, Jun-Sing Wang, Hayato Tada, Masa-aki Kawashiri, Akihiro Inazu, Masakazu Yamagishi, Tomohiro Katsuya, Eitaro Nakashima, Masahiro Nakatochi, Ken Yamamoto, Mitsuhiro Yokota, Yukihide Momozawa, Jerome I. Rotter, Eric S. Lander, Daniel J. Rader, John Danesh, Diego Ardissino, Stacey Gabriel, Cristen J. Willer, Goncalo R. Abecasis, Danish Saleheen, Michiaki Kubo, Norihiro Kato, Yii-Der Ida Chen, Frederick E. Dewey and Sekar Kathiresan

Circulation Research. 2017;121:81-88, originally published May 15, 2017
https://doi.org/10.1161/CIRCRESAHA.117.311145

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Analysis of Cardiac Myocyte Maturation Using CASAAV, a Platform for Rapid Dissection of Cardiac Myocyte Gene Function In VivoNovelty and Significance
Yuxuan Guo, Nathan J. VanDusen, Lina Zhang, Weiliang Gu, Isha Sethi, Silvia Guatimosim, Qing Ma, Blake D. Jardin, Yulan Ai, Donghui Zhang, Biyi Chen, Ang Guo, Guo-Cheng Yuan, Long-Sheng Song and William T. Pu

Circulation Research. 2017;120:1874-1888, originally published March 29, 2017
https://doi.org/10.1161/CIRCRESAHA.116.310283

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CASAAV Technology to Examine Regulators of Heart FailureCause or Effect
Ying Fu and Robin M. Shaw

Circulation Research. 2017;120:1846-1848, originally published June 8, 2017
https://doi.org/10.1161/CIRCRESAHA.117.311074

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Genome-Wide Analysis of DNA Methylation and Acute Coronary SyndromeNovelty and Significance
Jun Li, Xiaoyan Zhu, Kuai Yu, Haijing Jiang, Yizhi Zhang, Siyun Deng, Longxian Cheng, Xuezhen Liu, Jia Zhong, Xiaomin Zhang, Meian He, Weihong Chen, Jing Yuan, Ming Gao, Yansen Bai, Xu Han, Bing Liu, Xiaoting Luo, Wenhua Mei, Xiaosheng He, Shunchang Sun, Liyun Zhang, Hesong Zeng, Huizhen Sun, Chuanyao Liu, Yanjun Guo, Bing Zhang, Zhihong Zhang, Jinyan Huang, An Pan, Yu Yuan, Francesca Angileri, Bingxia Ming, Fang Zheng, Qiutang Zeng, Xiaobo Mao, Yudong Peng, Yi Mao, Ping He, Qing K. Wang, Lu Qi, Frank B. Hu, Liming Liang and Tangchun Wu

Circulation Research. 2017;120:1754-1767, originally published March 27, 2017
https://doi.org/10.1161/CIRCRESAHA.116.310324

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A Mutation in the G-Protein Gene GNB2 Causes Familial Sinus Node and Atrioventricular Conduction DysfunctionNovelty and Significance
Birgit Stallmeyer, Johanna Kuß, Stefan Kotthoff, Sven Zumhagen, Kirsty Vowinkel, Susanne Rinné, Lina A. Matschke, Corinna Friedrich, Ellen Schulze-Bahr, Stephan Rust, Guiscard Seebohm, Niels Decher and Eric Schulze-Bahr

Circulation Research. 2017;120:e33-e44, originally published February 20, 2017
https://doi.org/10.1161/CIRCRESAHA.116.310112

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Oliver Smithies, DPhil1925–2017
Jeffrey Robbins

Circulation Research. 2017;120:1535-1536, originally published May 11, 2017
https://doi.org/10.1161/CIRCRESAHA.117.311123

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Pacing DiscoveryG-Protein β Subunit Mutations in Sinus Node Dysfunction
Elisabeth M. Lodder, Arie O. Verkerk and Connie R. Bezzina

Circulation Research. 2017;120:1524-1526, originally published May 11, 2017
https://doi.org/10.1161/CIRCRESAHA.117.310953

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A Comprehensive TALEN-Based Knockout Library for Generating Human-Induced Pluripotent Stem Cell–Based Models for Cardiovascular DiseasesNovelty and Significance
Ioannis Karakikes, Vittavat Termglinchan, Diana A. Cepeda, Jaecheol Lee, Sebastian Diecke, Ayal Hendel, Ilanit Itzhaki, Mohamed Ameen, Rajani Shrestha, Haodi Wu, Ning Ma, Ning-Yi Shao, Timon Seeger, Nicole Woo, Kitchener D. Wilson, Elena Matsa, Matthew H. Porteus, Vittorio Sebastiano and Joseph C. Wu

Circulation Research. 2017;120:1561-1571, originally published February 28, 2017
https://doi.org/10.1161/CIRCRESAHA.116.309948

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