Lipids and Cholesterol

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The CCC Complex COMManDs Control of LDL Cholesterol Levels
Michael F. Keating and Anna C. Calkin

Circulation Research. 2018;122:1629-1631, originally published June 7, 2018
https://doi.org/10.1161/CIRCRESAHA.118.313074

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Alan R. TallThe Downs and (Mostly) Ups of a Life in Science
Susan Ince

Circulation Research. 2018;122:1638-1641, originally published June 7, 2018
https://doi.org/10.1161/CIRCRESAHA.118.313378

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The COMMD Family Regulates Plasma LDL Levels and Attenuates Atherosclerosis Through Stabilizing the CCC Complex in Endosomal LDLR TraffickingNovelty and Significance
Alina Fedoseienko, Melinde Wijers, Justina C. Wolters, Daphne Dekker, Marieke Smit, Nicolette Huijkman, Niels Kloosterhuis, Helene Klug, Aloys Schepers, Ko Willems van Dijk, Johannes H.M. Levels, Daniel D. Billadeau, Marten H. Hofker, Jan van Deursen, Marit Westerterp, Ezra Burstein, Jan Albert Kuivenhoven and Bart van de Sluis

Circulation Research. 2018;122:1648-1660, originally published March 15, 2018
https://doi.org/10.1161/CIRCRESAHA.117.312004

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PCSK9From Basic Science Discoveries to Clinical Trials
Michael D. Shapiro, Hagai Tavori and Sergio Fazio

Circulation Research. 2018;122:1420-1438, originally published May 10, 2018
https://doi.org/10.1161/CIRCRESAHA.118.311227

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Lysosomal Cholesterol Hydrolysis Couples Efferocytosis to Anti-Inflammatory Oxysterol ProductionNovelty and Significance
Manon Viaud, Stoyan Ivanov, Nemanja Vujic, Madalina Duta-Mare, Lazaro-Emilio Aira, Thibault Barouillet, Elsa Garcia, Francois Orange, Isabelle Dugail, Isabelle Hainault, Christian Stehlik, Sandrine Marchetti, Laurent Boyer, Rodolphe Guinamard, Fabienne Foufelle, Andrea Bochem, Kees G. Hovingh, Edward B. Thorp, Emmanuel L. Gautier, Dagmar Kratky, Paul Dasilva-Jardine and Laurent Yvan-Charvet

Circulation Research. 2018;122:1369-1384, originally published March 9, 2018
https://doi.org/10.1161/CIRCRESAHA.117.312333

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Revisiting Old FriendsSortilin-1, Low-Density Lipoprotein Receptor, and Prorenin Receptor as Modulators of Lipoprotein and Energy Metabolism
Alanna Strong

Circulation Research. 2018;122:652-654, originally published March 1, 2018
https://doi.org/10.1161/CIRCRESAHA.118.312656

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(Pro)renin Receptor Inhibition Reprograms Hepatic Lipid Metabolism and Protects Mice From Diet-Induced Obesity and HepatosteatosisNovelty and Significance
Liwei Ren, Yuan Sun, Hong Lu, Dien Ye, Lijuan Han, Na Wang, Alan Daugherty, Furong Li, Miaomiao Wang, Fengting Su, Wenjun Tao, Jie Sun, Noam Zelcer, Adam E. Mullick, A.H. Jan Danser, Yizhou Jiang, Yongcheng He, Xiongzhong Ruan and Xifeng Lu

Circulation Research. 2018;122:730-741, originally published January 4, 2018
https://doi.org/10.1161/CIRCRESAHA.117.312422

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Urinary Prostaglandin MetabolitesAn Incomplete Reckoning and a Flush to Judgment
Tilo Grosser, Ali Naji and Garret A. FitzGerald

Circulation Research. 2018;122:537-539, originally published February 15, 2018
https://doi.org/10.1161/CIRCRESAHA.118.312616

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Autophagy Is Required for Sortilin-Mediated Degradation of Apolipoprotein B100Novelty and Significance
Jaume Amengual, Liang Guo, Alanna Strong, Julio Madrigal-Matute, Haizhen Wang, Susmita Kaushik, Jeffrey L. Brodsky, Daniel J. Rader, Ana Maria Cuervo and Edward A. Fisher

Circulation Research. 2018;122:568-582, originally published January 4, 2018
https://doi.org/10.1161/CIRCRESAHA.117.311240

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Novel Reversible Model of Atherosclerosis and Regression Using Oligonucleotide Regulation of the LDL ReceptorNovelty and Significance
Debapriya Basu, Yunying Hu, Lesley-Ann Huggins, Adam E. Mullick, Mark J. Graham, Tomasz Wietecha, Shelley Barnhart, Allison Mogul, Katharina Pfeiffer, Andreas Zirlik, Edward A. Fisher, Karin E. Bornfeldt, Florian Willecke and Ira J. Goldberg

Circulation Research. 2018;122:560-567, originally published January 10, 2018
https://doi.org/10.1161/CIRCRESAHA.117.311361

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