Vascular Disease

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Neutrophil Activation of Endothelial Cell-Expressed TRPM2 Mediates Transendothelial Neutrophil Migration and Vascular InjuryNovelty and Significance
Manish Mittal, Saroj Nepal, Yoshikazu Tsukasaki, Claudie M. Hecquet, Dheeraj Soni, Jalees Rehman, Chinnaswamy Tiruppathi and Asrar B. Malik

Circulation Research. 2017;121:1081-1091, originally published August 8, 2017
https://doi.org/10.1161/CIRCRESAHA.117.311747

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Letter by Calderón-Gerstein Regarding Article, “Environmental Determinants of Cardiovascular Disease”
Walter Calderón-Gerstein

Circulation Research. 2017;121:e80, originally published September 28, 2017
https://doi.org/10.1161/CIRCRESAHA.117.311804

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Mast Cells Granular Contents Are Crucial for Deep Vein Thrombosis in MiceNovelty and Significance
Tatyana Ponomaryov, Holly Payne, Larissa Fabritz, Denisa D. Wagner and Alexander Brill

Circulation Research. 2017;121:941-950, originally published July 24, 2017
https://doi.org/10.1161/CIRCRESAHA.117.311185

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TLR2 Plays a Key Role in Platelet Hyperreactivity and Accelerated Thrombosis Associated With HyperlipidemiaNovelty and Significance
Sudipta Biswas, Alejandro Zimman, Detao Gao, Tatiana V. Byzova and Eugene A. Podrez

Circulation Research. 2017;121:951-962, originally published August 3, 2017
https://doi.org/10.1161/CIRCRESAHA.117.311069

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TPL2 (Therapeutic Targeting Tumor Progression Locus-2)/ATF4 (Activating Transcription Factor-4)/SDF1α (Chemokine Stromal Cell-Derived Factor-α) Axis Suppresses Diabetic RetinopathyNovelty and Significance
De-Wei Lai, Keng-Hung Lin, Wayne Huey-Herng Sheu, Maw-Rong Lee, Chung-Yu Chen, Wen-Jane Lee, Yi-Wen Hung, Chin-Chang Shen, Tsung-Ju Chung, Shing-Hwa Liu and Meei-Ling Sheu

Circulation Research. 2017;121:e37-e52, originally published July 19, 2017
https://doi.org/10.1161/CIRCRESAHA.117.311066

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Smooth Muscle Differentiation Control Comes Full CircleThe Circular Noncoding RNA, circActa2, Functions as a miRNA Sponge to Fine-Tune α-SMA Expression
Mary C.M. Weiser-Evans

Circulation Research. 2017;121:591-593, originally published August 31, 2017
https://doi.org/10.1161/CIRCRESAHA.117.311722

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A Novel Regulatory Mechanism of Smooth Muscle α-Actin Expression by NRG-1/circACTA2/miR-548f-5p AxisNovelty and Significance
Yan Sun, Zhan Yang, Bin Zheng, Xin-hua Zhang, Man-li Zhang, Xue-shan Zhao, Hong-ye Zhao, Toru Suzuki and Jin-kun Wen

Circulation Research. 2017;121:628-635, originally published July 11, 2017
https://doi.org/10.1161/CIRCRESAHA.117.311441

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ARHGAP18 Protects Against Thoracic Aortic Aneurysm Formation by Mitigating the Synthetic and Proinflammatory Smooth Muscle Cell PhenotypeNovelty and Significance
Renjing Liu, Lisa Lo, Angelina J. Lay, Yang Zhao, Ka Ka Ting, Elizabeth N. Robertson, Andrew G. Sherrah, Sorour Jarrah, Haibo Li, Zhaoxiong Zhou, Brett D. Hambly, David R. Richmond, Richmond W. Jeremy, Paul G. Bannon, Mathew A. Vadas and Jennifer R. Gamble

Circulation Research. 2017;121:512-524, originally published July 12, 2017
https://doi.org/10.1161/CIRCRESAHA.117.310692

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Genetic Deletion of NADPH Oxidase 1 Rescues Microvascular Function in Mice With Metabolic DiseaseNovelty and Significance
Jennifer A. Thompson, Sebastian Larion, James D. Mintz, Eric J. Belin de Chantemèle, David J. Fulton and David W. Stepp

Circulation Research. 2017;121:502-511, originally published July 6, 2017
https://doi.org/10.1161/CIRCRESAHA.116.309965

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Mitochondrial Complex IV Subunit 4 Isoform 2 Is Essential for Acute Pulmonary Oxygen SensingNovelty and Significance
Natascha Sommer, Maik Hüttemann, Oleg Pak, Susan Scheibe, Fenja Knoepp, Christopher Sinkler, Monika Malczyk, Mareike Gierhardt, Azadeh Esfandiary, Simone Kraut, Felix Jonas, Christine Veith, Siddhesh Aras, Akylbek Sydykov, Nasim Alebrahimdehkordi, Klaudia Giehl, Matthias Hecker, Ralf P. Brandes, Werner Seeger, Friedrich Grimminger, Hossein A. Ghofrani, Ralph T. Schermuly, Lawrence I. Grossman and Norbert Weissmann

Circulation Research. 2017;121:424-438, originally published June 15, 2017
https://doi.org/10.1161/CIRCRESAHA.116.310482

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