Response by Glisic et al to Letter Regarding Article, “Associations of Endogenous Estradiol and Testosterone Levels With Plaque Composition and Risk of Stroke in Subjects With Carotid Atherosclerosis”
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We appreciate the comments by Drs Scarabin and Scarabin-Carre on our recent publication.1 In this population-based study among postmenopausal women and elderly men, we identified sex differences in the association between estradiol, carotid plaque composition, and risk of stroke in men and women with carotid atherosclerosis. Our main findings indicate that circulating estradiol is associated with, both, presence of vulnerable carotid plaque and risk of stroke in postmenopausal women. Previously, we have, also, found that high levels of estradiol are associated with increased risk of type 2 diabetes mellitus in postmenopausal women and adverse cardiovascular profile, providing additional evidence on potential harmful effects of estradiol on cardiometabolic health in elderly women.2, …